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Page 1
A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties.
Mol Ther. 2021 May 5;29(5):1729-1743. doi: 10.1016/j.ymthe.2021.01.020. Epub 2021 Jan 21.
Mol Ther. 2021.
PMID: 33484965
Free PMC article.
Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry.
Harrison RA, Engen JR.
Harrison RA, et al.
Curr Opin Struct Biol. 2016 Dec;41:187-193. doi: 10.1016/j.sbi.2016.08.003. Epub 2016 Aug 20.
Curr Opin Struct Biol. 2016.
PMID: 27552080
Free PMC article.
Review.
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ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance.
Jang SC, Economides KD, Moniz RJ, Sia CL, Lewis N, McCoy C, Zi T, Zhang K, Harrison RA, Lim J, Dey J, Grenley M, Kirwin K, Ross NL, Bourdeau R, Villiger-Oberbek A, Estes S, Xu K, Sanchez-Salazar J, Dooley K, Dahlberg WK, Williams DE, Sathyanarayanan S.
Jang SC, et al. Among authors: harrison ra.
Commun Biol. 2021 Apr 22;4(1):497. doi: 10.1038/s42003-021-02004-5.
Commun Biol. 2021.
PMID: 33888863
Free PMC article.
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Structural Dynamics in Ras and Related Proteins upon Nucleotide Switching.
Harrison RA, Lu J, Carrasco M, Hunter J, Manandhar A, Gondi S, Westover KD, Engen JR.
Harrison RA, et al.
J Mol Biol. 2016 Nov 20;428(23):4723-4735. doi: 10.1016/j.jmb.2016.10.017. Epub 2016 Oct 14.
J Mol Biol. 2016.
PMID: 27751724
Free PMC article.
Item in Clipboard
Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor.
Lim SM, Westover KD, Ficarro SB, Harrison RA, Choi HG, Pacold ME, Carrasco M, Hunter J, Kim ND, Xie T, Sim T, Jänne PA, Meyerson M, Marto JA, Engen JR, Gray NS.
Lim SM, et al. Among authors: harrison ra.
Angew Chem Int Ed Engl. 2014 Jan 3;53(1):199-204. doi: 10.1002/anie.201307387. Epub 2013 Nov 20.
Angew Chem Int Ed Engl. 2014.
PMID: 24259466
Free PMC article.
Item in Clipboard
KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.
Lu J, Harrison RA, Li L, Zeng M, Gondi S, Scott D, Gray NS, Engen JR, Westover KD.
Lu J, et al. Among authors: harrison ra.
Structure. 2017 Sep 5;25(9):1442-1448.e3. doi: 10.1016/j.str.2017.07.003. Epub 2017 Aug 3.
Structure. 2017.
PMID: 28781083
Free PMC article.
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Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.
Gu C, Lamb ML, Johannes JW, Sylvester MA, Eisman MS, Harrison RA, Hu H, Kazmirski S, Mikule K, Peng B, Su N, Wang W, Ye Q, Zheng X, Lyne PD, Scott DA.
Gu C, et al. Among authors: harrison ra.
Bioorg Med Chem Lett. 2016 Oct 1;26(19):4775-4780. doi: 10.1016/j.bmcl.2016.08.030. Epub 2016 Aug 12.
Bioorg Med Chem Lett. 2016.
PMID: 27578247
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